Cosmic rays go hand-in-hand with violent and energetic astrophysical conditions. They are an active agent within galactic and circumgalactic ecosystems, where they can deposit energy and momentum, modify the circulation of baryons, and even have the potential to regulate star-formation on local and galactic scales. Their influence in galaxies can be probed using observable signatures across the electromagnetic spectrum, with high energy radiation being particularly important to determine their energy budget, feedback power and hydrodynamic effects. In this talk, I will discuss some of the astrophysical impacts hadronic and leptonic cosmic rays can have in and around galaxies, how their influence can be probed using signatures in X-rays and gamma-rays, and the opportunities soon to open-up that will allow us to map-out the multi-scale effects of cosmic rays in galaxies near and far.