It has been ten years since IceCube, a neutrino detector embedded in the Antarctic glacier, has detected high-energy astrophysical neutrinos. In this informal talk, I will report on the latest results from IceCube and point out opportunities for searches for new physics. In particular, I will describe the recent observation of NGC 1068 and the detection of our galaxy in neutrinos. I will present recent proposals to search for new physics with these sources. Finally, I will provide an update on searches for light sterile neutrinos with high-energy atmospheric neutrinos.